Loss of RE-1 silencing transcription factor accelerates exocrine damage from pancreatic injury.

ABSTRACT: Regulation of pancreas plasticity is critical for preventing injury and promoting regeneration upon tissue damage. The intricate process of pancreatic differentiation is governed by an orchestrated network of positive and negative transcription factors for appropriate gene expression. While the transcriptional repressor REST is well characterized as a silencer of neuronal genes in non-neuronal cells, the role of REST in regulating exocrine pancreas cell identity remains largely unexplored. Rest expression is increased upon injury in the mouse pancreas, such as induced acute and chronic pancreatitis and ductal adenocarcinoma. At the cellular level, Rest expression is lower in mature acinar cells compared with pancreas progenitor and ductal cells. To investigate the role of REST activity in

SUBMITTER: Bray JK 

PROVIDER: S-EPMC7033132 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature