GHz Ultrasonic Chip-Scale Device Induces Ion Channel Stimulation in Human Neural Cells.

ABSTRACT: Emergent trends in the device development for neural prosthetics have focused on establishing stimulus localization, improving longevity through immune compatibility, reducing energy re-quirements, and embedding active control in the devices. Ultrasound stimulation can single-handedly address several of these challenges. Ultrasonic stimulus of neurons has been studied extensively from 100 kHz to 10 MHz, with high penetration but less localization. In this paper, a chip-scale device consisting of piezoelectric Aluminum Nitride ultrasonic transducers was engineered to deliver gigahertz (GHz) ultrasonic stimulus to the human neural cells. These devices provide a path towards complementary metal oxide semiconductor (CMOS) integration towards fully controllable neural devices. At GHz frequencie

SUBMITTER: Balasubramanian PS 

PROVIDER: S-EPMC7033194 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature