Mechanism underlying starvation-dependent modulation of olfactory behavior in Drosophila larva.

ABSTRACT: Starvation enhances olfactory sensitivity that encourage animals to search for food. The molecular mechanisms that enable sensory neurons to remain flexible and adapt to a particular internal state remain poorly understood. Here, we study the roles of GABA and insulin signaling in starvation-dependent modulation of olfactory sensory neuron (OSN) function in the Drosophila larva. We show that GABA_B-receptor and insulin-receptor play important roles during OSN modulation. Using an OSN-specific gene expression analysis, we explore downstream targets of insulin signaling in OSNs. Our results suggest that insulin and GABA signaling pathways interact within OSNs and modulate OSN function by impacting olfactory information processing. We further show that manipulating these signaling p

SUBMITTER: Slankster E 

PROVIDER: S-EPMC7033209 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature