New participant stratification and combination of urinary biomarkers and confounders could improve diagnostic accuracy for overactive bladder.

ABSTRACT: Overactive bladder (OAB) is a highly prevalent symptom complex characterised by symptoms of urinary urgency, increased frequency, nocturia, with or without urge incontinence; in the absence of proven infection or other obvious pathology. The underlying pathophysiology of idiopathic OAB is not clearly known and the existence of several phenotypes has been proposed. Current diagnostic approaches are based on discordant measures, suffer from subjectivity and are incapable of detecting the proposed OAB phenotypes. In this study, cluster analysis was used as an objective approach for phenotyping participants based on their OAB characteristic symptoms and led to the identification of a low OAB symptomatic score group (cluster 1) and a high OAB symptomatic score group (cluster 2). Furthermore, th

SUBMITTER: Firouzmand S 

PROVIDER: S-EPMC7033236 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature