A Nonpeptide Oxytocin Receptor Agonist for a Durable Relief of Inflammatory Pain.

ABSTRACT: Oxytocin possesses several physiological and social functions, among which an important analgesic effect. For this purpose, oxytocin binds mainly to its unique receptor, both in the central nervous system and in the peripheral nociceptive terminal axon in the skin. However, despite its interesting analgesic properties and its current use in clinics to facilitate labor, oxytocin is not used in pain treatment. Indeed, it is rapidly metabolized, with a half-life in the blood circulation estimated at five minutes and in cerebrospinal fluid around twenty minutes in humans and rats. Moreover, oxytocin itself suffers from several additional drawbacks: a lack of specificity, an extremely poor oral absorption and distribution, and finally, a lack of patentability. Recently, a first non-peptide full

SUBMITTER: Hilfiger L 

PROVIDER: S-EPMC7033278 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature