The safety and efficacy of steroid treatment for acute spinal cord injury: A Systematic Review and meta-analysis.

ABSTRACT:

Introduction

The role for steroids in acute spinal cord injury (ASCI) remains unclear; while some studies have demonstrated the risks of steroids outweigh the benefits,a meta-analyses conducted on heterogeneous patient populations have shown significant motor improvement at short-term but not at long-term follow-up. Given the heterogeneity of the patient population in previous meta-analyses and the publication of a recent trial not included in these meta-analyses, we sought to re-assess and update the safety and short-term and long-term efficacy of steroid treatment following ASCI in a more homogeneous patient population.

Materials and methods

A literature search was conducted on PubMed, EMBASE and Cochrane Library through June 2019 for studies evaluating the utility of ster

SUBMITTER: Sultan I 

PROVIDER: S-EPMC7033344 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature