Effects of a gintonin-enriched fraction on hair growth: an in vitro and in vivo study.

ABSTRACT:

Background

Ginseng has been widely used as a health-promoting tonic. Gintonin present in ginseng acts as a lysophosphatidic acid (LPA) receptor ligand that activates six LPA receptor subtypes. The LPA6 subtype plays a key role in normal hair growth, and mutations in the LPA6 receptor impair normal human hair growth. Currently, human hair loss and alopecia are concerning issues that affect peoples' social and day-to-day lives.

Objective

We investigated the in vitro and in vivo effects of a gintonin-enriched fraction (GEF) on mouse hair growth.

Methods

Human hair follicle dermal papilla cells (HFDPCs) and six-week-old male C57BL/6 mice were used. The mice were divided into the four groups: control, 1% minoxidil, 0.75% GEF, and 1.5% GEF. The dorsal hair was

SUBMITTER: Lee NE 

PROVIDER: S-EPMC7033365 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature