Caffsim: simulation of plasma caffeine concentrations implemented as an R package and Web-applications.

ABSTRACT: Caffeine is a naturally-occurring central nervous system stimulant found in plant constituents including coffee, cocoa beans, and tea leaves. Consumption of caffeine through imbibing caffeinated drinks is rapidly growing among children, adolescents, and young adults, who tend to be more caffeine-sensitive than the rest of the general public; consequently, caffeine-related toxicities among these groups are also growing in number. However, a quantitative and interactive tool for predicting the plasma caffeine concentration that may lead to caffeine intoxication has yet to be developed. Using the previously established population-pharmacokinetic model, we developed "caffsim" R package and its web-based applications using Shiny and EDISON (EDucation-research Integration through Simulation On t

SUBMITTER: Han S 

PROVIDER: S-EPMC7033381 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature