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Rheumatoid Arthritis Patients, Both Newly Diagnosed and Methotrexate Treated, Show More DNA Methylation Differences in CD4⁺ Memory Than in CD4⁺ Naive T Cells.

ABSTRACT: Background: Differences in DNA methylation have been reported in B and T lymphocyte populations, including CD4⁺ T cells, isolated from rheumatoid arthritis (RA) patients when compared to healthy controls. CD4⁺ T cells are a heterogeneous cell type with subpopulations displaying distinct DNA methylation patterns. In this study, we investigated DNA methylation using reduced representation bisulfite sequencing in two CD4⁺ T cell populations (CD4⁺ memory and naïve cells) in three groups: newly diagnosed, disease modifying antirheumatic drugs (DMARD) naïve RA patients (N = 11), methotrexate (MTX) treated RA patients (N = 18), and healthy controls (N = 9) matched for age, gender and smoking status. Results: Analyses o

SUBMITTER: Guderud K

PROVIDER: S-EPMC7033478 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Rheumatoid Arthritis Patients, Both Newly Diagnosed and Methotrexate Treated, Show More DNA Methylation Differences in CD4⁺ Memory Than in CD4⁺ Naive T Cells.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Rheumatoid Arthritis Patients, Both Newly Diagnosed and Methotrexate Treated, Show More DNA Methylation Differences in CD4+ Memory Than in CD4+ Naive T Cells.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Rheumatoid Arthritis Patients, Both Newly Diagnosed and Methotrexate Treated, Show More DNA Methylation Differences in CD4⁺ Memory Than in CD4⁺ Naive T Cells.