A new paradigm for lung-conservative total liquid ventilation.

ABSTRACT:

Background

Total liquid ventilation (TLV) of the lungs could provide radically new benefits in critically ill patients requiring lung lavage or ultra-fast cooling after cardiac arrest. It consists in an initial filling of the lungs with perfluorocarbons and subsequent tidal ventilation using a dedicated liquid ventilator. Here, we propose a new paradigm for a lung-conservative TLV using pulmonary volumes of perfluorocarbons below functional residual capacity (FRC).

Methods and findings

Using a dedicated technology, we showed that perfluorocarbon end-expiratory volumes could be maintained below expected FRC and lead to better respiratory recovery, preserved lung structure and accelerated evaporation of liquid residues as compared to complete lung filling in piglets. Such TLV

SUBMITTER: Kohlhauer M 

PROVIDER: S-EPMC7033528 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature