Race, Natriuretic Peptides, and High-Carbohydrate Challenge: A Clinical Trial.

ABSTRACT:

Rationale

Lower NP (natriuretic peptide) levels may contribute to the development of cardiometabolic diseases. Blacks have lower NP levels than middle-aged and older white adults. A high-carbohydrate challenge causes an upregulation of a negative ANP regulator microRNA-425 (miR-425), which reduces ANP (atrial-NP) levels in whites.

Objectives

We designed a prospective trial to study racial differences in (1) NP levels among young adults, (2) NP response to a high-carbohydrate challenge, and (3) explore underlying mechanisms for race-based differences.

Methods and results

Healthy self-identified blacks and whites received 3 days of study diet followed by a high-carbohydrate challenge. Gene expression from whole blood RNA was assessed in the trial participants. Ad

SUBMITTER: Patel N 

PROVIDER: S-EPMC7033629 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature