Risk of Stillbirth for Fetuses With Specific Birth Defects.

ABSTRACT:

Objective

To estimate the risk of stillbirth (fetal death at 20 weeks of gestation or more) associated with specific birth defects.

Methods

We identified a population-based retrospective cohort of neonates and fetuses with selected major birth defects and without known or strongly suspected chromosomal or single-gene disorders from active birth defects surveillance programs in nine states. Abstracted medical records were reviewed by clinical geneticists to confirm and classify all birth defects and birth defect patterns. We estimated risks of stillbirth specific to birth defects among pregnancies overall and among those with isolated birth defects; potential bias owing to elective termination was quantified.

Results

Of 19,170 eligible neonates and fetuses with birth d

SUBMITTER: Heinke D 

PROVIDER: S-EPMC7033649 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature