Augmented astrocyte microdomain Ca²⁺ dynamics and parenchymal arteriole tone in angiotensin II-infused hypertensive mice.

ABSTRACT: Hypertension is an important contributor to cognitive decline but the underlying mechanisms are unknown. Although much focus has been placed on the effect of hypertension on vascular function, less is understood of its effects on nonvascular cells. Because astrocytes and parenchymal arterioles (PA) form a functional unit (neurovascular unit), we tested the hypothesis that hypertension-induced changes in PA tone concomitantly increases astrocyte Ca²⁺ . We used cortical brain slices from 8-week-old mice to measure myogenic responses from pressurized and perfused PA. Chronic hypertension was induced in mice by 28-day angiotensin II (Ang II) infusion; PA resting tone and myogenic responses increased significantly. In addition, chronic hypertension significantly increased spontaneous

SUBMITTER: Diaz JR 

PROVIDER: S-EPMC7033753 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature