Effects of topical polydeoxyribonucleotide on radiation-induced oral mucositis.

ABSTRACT:

Introduction

Oral mucositis, the most common adverse effect of radiotherapy (RT) and/or chemotherapy is observed in almost 97% of patients with head and neck cancer. Although several agents like corticosteroids, lidocaine and vitamins are available for its prevention or management, results are often disappointing. Here we report on the effects of a topically applied, highly purified natural deoxyribonucleic acid from sturgeon gonads on three cases of moderate to severe oral mucositis in patients with head and neck cancer.

Case description

Three patients who had undergone RT and/or chemotherapy received an oral spray containing sodium salt-based natural deoxyribonucleic acid (PDRN) for Grade 3 oral mucositis. Treatment continued for one month after the end of RT. No patient r

SUBMITTER: Podlesko AM 

PROVIDER: S-EPMC7033775 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature