Exercise is Associated With Impaired Left Ventricular Systolic Function in Patients With Lamin A/C Genotype.

ABSTRACT: Background Lamin A/C cardiomyopathy is a malignant and highly penetrant inheritable cardiomyopathy. Competitive sports have been associated with adverse events in these patients, but data on recreational exercise are lacking. We aimed to explore associations between exercise exposure and disease severity in patients with lamin A/C genotype. Methods and Results Lamin A/C genotype positive patients answered a questionnaire on exercise habits from age 7 years until genetic diagnosis. We recorded exercise hours >3 metabolic equivalents and calculated cumulative lifetime exercise. Patients were grouped in active or sedate based on lifetime exercise hours above or below median. We performed echocardiography, 12-lead ECG, Holter monitoring, and biomarkers including NT-proBNP (N-terminal pro-B-typ

SUBMITTER: Skjolsvik ET 

PROVIDER: S-EPMC7033829 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature