Frequency of Potential Drug-Drug Interactions in the Changing Field of HCV Therapy.

ABSTRACT:

Background

With the introduction of direct-acting antivirals (DAAs) for hepatitis C virus (HCV) infection, drug-drug interactions (DDIs) emerged as significant challenge. Since then, HCV therapy and the infected population have rapidly changed. So far, very limited data are available regarding the clinical relevance of DDIs when using most modern DAA regimens. We aimed to assess how the importance of DDIs has evolved over time.

Methods

From January 2014 to July 2018, 668 consecutive HCV patients were evaluated for their outpatient medication and assessed for DDIs with DAAs. Different time periods were defined based on market approval of key DAAs: A (01/2014-11/2014), B (11/2014-08/2016), and C (08/2016-07/2018).

Results

The frequency of patients with real-world DDIs w

SUBMITTER: Schulte B 

PROVIDER: S-EPMC7033915 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature