Highly coupled transport can be achieved in free-exchange transport models.

ABSTRACT: Secondary active transporters couple the transport of an ion species down its concentration gradient to the uphill transport of another substrate. Despite the importance of secondary active transport to multidrug resistance, metabolite transport, and nutrient acquisition, among other biological processes, the microscopic steps of the coupling mechanism are not well understood. Often, transport models illustrate coupling mechanisms through a limited number of "major" conformations or states, yet recent studies have indicated that at least some transporters violate these models. The small multidrug resistance transporter EmrE has been shown to couple proton influx to multidrug efflux via a mechanism that incorporates both "major" and "minor" conformational states and transitions. The resulti

SUBMITTER: Hussey GA 

PROVIDER: S-EPMC7034097 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature