Understanding nanoparticle flow with a new in vitro experimental and computational approach using hydrogel channels.

ABSTRACT: Nanoparticles (NPs) are considered as one of the most promising drug delivery vehicles and a next-generation solution for current medical challenges. In this context, variables related to flow of NPs such as the quantity of NPs lost during transport and flow trajectory greatly affect the clinical efficiency of NP drug delivery systems. Currently, there is little knowledge of the physical mechanisms dominating NP flow inside the human body due to the limitations of available experimental tools for mimicking complex physiological environments at the preclinical stage. Here, we report a coupled experimental and computational fluid dynamics (CFD)-based novel in vitro approach to predict the flow velocity and binding of NP drug delivery systems during transport through vasculature. Poly(hydroxy

SUBMITTER: Boutchuen A 

PROVIDER: S-EPMC7034222 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature