High genetic risk score is associated with early disease onset, damage accrual and decreased survival in systemic lupus erythematosus.

ABSTRACT:

Objectives

To investigate associations between a high genetic disease risk and disease severity in patients with systemic lupus erythematosus (SLE).

Methods

Patients with SLE (n=1001, discovery cohort and n=5524, replication cohort) and healthy controls (n=2802 and n=9859) were genotyped using a 200K Immunochip single nucleotide polymorphism array. A genetic risk score (GRS) was assigned to each individual based on 57 SLE risk loci.

Results

SLE was more prevalent in the high, compared with the low, GRS-quartile (OR 12.32 (9.53 to 15.71), p=7.9×10^-86 and OR 7.48 (6.73 to 8.32), p=2.2×10^-304 for the discovery and the replication cohorts, respectively). In the discovery cohort, patients in the high GRS-quartile had a 6-year earlier mean disease onse

SUBMITTER: Reid S 

PROVIDER: S-EPMC7034364 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature