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An expanded parenchymal CD8+ T cell clone in GABAA receptor encephalitis.

ABSTRACT: The role of T cells in autoimmune encephalitis syndromes with autoantibodies against cell surface antigens is still enigmatic. Here we analyzed the T cell receptor repertoires of CD8+ and CD4+ T cells in a patient with "idiopathic" gamma-aminobutyric-acid-A receptor (GABAA -R) encephalitis by next-generation sequencing and single-cell analyses. We identified a CD8+ T cell clone that was strongly expanded in the cerebrospinal fluid and in the hippocampus but not in the operculo-insular cortex. By contrast, CD4+ T cells were polyclonal in these tissues. Such a strong clonal expansion suggests that CD8+ T cells may play a significant role in the pathogenesis.

SUBMITTER: Bracher A

PROVIDER: S-EPMC7034500 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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An expanded parenchymal CD8+ T cell clone in GABAA receptor encephalitis.

Bracher Aline A Alcalá Carmen C Ferrer Jaime J Melzer Nico N Hohlfeld Reinhard R Casanova Bonaventura B Beltrán Eduardo E Dornmair Klaus K

Annals of clinical and translational neurology 20200114 2

The role of T cells in autoimmune encephalitis syndromes with autoantibodies against cell surface antigens is still enigmatic. Here we analyzed the T cell receptor repertoires of CD8+ and CD4+ T cells in a patient with "idiopathic" gamma-aminobutyric-acid-A receptor (GABAA -R) encephalitis by next-generation sequencing and single-cell analyses. We identified a CD8+ T cell clone that was strongly expanded in the cerebrospinal fluid and in the hippocampus but not in the operculo-insular ...[more]

PMID: 31943946

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Structural mechanisms of GABAA receptor autoimmune encephalitis.

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