CSF SerpinA1 in Creutzfeldt-Jakob disease and frontotemporal lobar degeneration.

ABSTRACT:

Objective

SerpinA1 (alpha-1 antitrypsin) is an acute inflammatory protein, which seems to play a role in neurodegeneration and neuroinflammation. In Alzheimer's disease and synucleinopathies, SerpinA1 is overexpressed in the brain and the cerebrospinal fluid (CSF) showing abnormal patterns of its charge isoforms. To date, no comprehensive studies explored SerpinA1 CSF isoforms in Creutzfeldt-Jakob disease (CJD) and frontotemporal lobar degeneration (FTLD).

Methods

Using a capillary isoelectric focusing immunoassay, we analyzed CSF SerpinA1 isoforms in control cases (n = 31) and patients with a definite or probable diagnosis of CJD (n=77) or FTLD (n = 30), belonging to several disease subtypes.

Results

The overall SerpinA1 signal was significantly higher than in contro

SUBMITTER: Abu-Rumeileh S 

PROVIDER: S-EPMC7034504 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature