A Latent Transition Analysis Model to Assess Change in Cognitive States over Three Occasions: Results from the Rush Memory and Aging Project.

ABSTRACT:

Background

Conceptualizing cognitive aging as a step-sequential process is useful in identifying particular stages of cognitive function and impairment.

Objective

We applied latent transition analysis (LTA) to determine 1) whether the underlying structure of cognitive profiles found at every measurement occasion are uniform across three waves of assessment, 2) whether class-instability is predictive of distal outcomes, and 3) whether class-reversions from impaired to non-impaired using latent modelling is lower than when using clinical criteria of mild cognitive impairment (MCI).

Methods

A mover-stayer LTA model with dementia as a distal outcome was specified to model transitions of ten neuropsychological measures over three annual waves in the Rush Memory and Aging P

SUBMITTER: Zammit AR 

PROVIDER: S-EPMC7034515 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature