An evolutionary, structural and functional overview of the mammalian TEAD1 and TEAD2 transcription factors.

ABSTRACT: TEAD proteins constitute a family of highly conserved transcription factors, characterized by a DNA-binding domain called the TEA domain and a protein-binding domain that permits association with transcriptional co-activators. TEAD proteins are unable to induce transcription on their own. They have to interact with transcriptional cofactors to do so. Once TEADs bind their co-activators, the different complexes formed are known to regulate the expression of genes that are crucial for embryonic development, important for organ formation (heart, muscles), and involved in cell death and proliferation. In the first part of this review we describe what is known of the structure of TEAD proteins. We then focus on two members of the family: TEAD1 and TEAD2. First the different transcriptional cofa

SUBMITTER: Landin-Malt A 

PROVIDER: S-EPMC7034536 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature