Using practice effects for targeted trials or sub-group analysis in Alzheimer's disease: How practice effects predict change over time.

ABSTRACT: OBJECTIVE:To describe the presence of practice effects in persons with Alzheimer disease (AD) or mild cognitive impairment (MCI) and to evaluate how practice effects affect cognitive progression and the outcome of clinical trials. METHODS:Using data from a meta-database consisting of 18 studies including participants from the Alzheimer disease Cooperative Study (ADCS) and the Alzheimer Disease Neuroimaging Initiative (ADNI) with ADAS-Cog11 as the primary outcome, we defined practice effects based on the improvement in the first two ADAS-Cog11 scores and then estimated the presence of practice effects and compared the cognitive progression between participants with and without practice effects. The robustness of practice effects was investigated using CDR SB, an outcome independent the defi

SUBMITTER: Wang G 

PROVIDER: S-EPMC7034859 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature