Palmitate induces apoptotic cell death and inflammasome activation in human placental macrophages.

ABSTRACT:

Introduction

There is an increasing prevalence of non-communicable diseases worldwide. Metabolic diseases such as obesity and gestational diabetes mellitus (GDM) increasingly affect women during pregnancy, which can harm pregnancy outcomes and the long-term health and wellbeing of exposed offspring. Both obesity and GDM have been associated with proinflammatory effects within the placenta, the critical organ governing fetal development.

Methods

The purpose of these studies was to model, in vitro, the effects of metabolic stress (high levels of glucose, insulin and saturated lipids) on placental macrophage biology, since these cells are the primary innate immune phagocyte within the placenta with roles in governing maternofetal immune tolerance and antimicrobial host defense.

SUBMITTER: Rogers LM 

PROVIDER: S-EPMC7034939 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature