Targeted induction of a silent fungal gene cluster encoding the bacteria-specific germination inhibitor fumigermin.

ABSTRACT: Microorganisms produce numerous secondary metabolites (SMs) with various biological activities. Many of their encoding gene clusters are silent under standard laboratory conditions because for their activation they need the ecological context, such as the presence of other microorganisms. The true ecological function of most SMs remains obscure, but understanding of both the activation of silent gene clusters and the ecological function of the produced compounds is of importance to reveal functional interactions in microbiomes. Here, we report the identification of an as-yet uncharacterized silent gene cluster of the fungus Aspergillus fumigatus, which is activated by the bacterium Streptomyces rapamycinicus during the bacterial-fungal interaction. The resulting natural product is the nove

SUBMITTER: Stroe MC 

PROVIDER: S-EPMC7034978 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature