Immature platelet fraction: A useful marker for identifying the cause of thrombocytopenia and predicting platelet recovery.

ABSTRACT:

Introduction

The assessment of bone marrow thrombopoietic activity in patients with thrombocytopenia is necessary to achieve an accurate diagnosis and administer effective treatment. We evaluated the discriminatory power of the immature platelet fraction (IPF) in differentiating hyperdestructive/consumptive thrombocytopenia from hypoproductive thrombocytopenia and its potential use as a predictive marker for platelet recovery.

Methods

In this observational study, platelet indices, including IPF, were measured in 105 healthy individuals, 27 patients with hyperdestructive/consumptive thrombocytopenia (all with immune thrombocytopenic purpura [ITP]), and 35 patients with hypoproductive thrombocytopenia (5 with aplastic anemia and 30 with cancer who were undergoing chemotherapy)

SUBMITTER: Jeon K 

PROVIDER: S-EPMC7035018 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature