The Transition from Evaluation to Selection Involves Neural Subspace Reorganization in Core Reward Regions.

ABSTRACT: Economic choice proceeds from evaluation, in which we contemplate options, to selection, in which we weigh options and choose one. These stages must be differentiated so that decision makers do not proceed to selection before evaluation is complete. We examined responses of neurons in two core reward regions, orbitofrontal (OFC) and ventromedial prefrontal cortex (vmPFC), during two-option choice with asynchronous offer presentation. Our data suggest that neurons selective during the first (presumed evaluation) and second (presumed comparison and selection) offer epochs come from a single pool. Stage transition is accompanied by a shift toward orthogonality in the low-dimensional population response manifold. Nonetheless, the relative position of each option in driving responses in the pop

SUBMITTER: Yoo SBM 

PROVIDER: S-EPMC7035164 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature