Ontology highlight
ABSTRACT:
SUBMITTER: Kallman A
PROVIDER: S-EPMC7035245 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Communications biology 20200221 1
Photoreceptor loss is a leading cause of blindness, but mechanisms underlying photoreceptor degeneration are not well understood. Treatment strategies would benefit from improved understanding of gene-expression patterns directing photoreceptor development, as many genes are implicated in both development and degeneration. Neural retina leucine zipper (NRL) is critical for rod photoreceptor genesis and degeneration, with NRL mutations known to cause enhanced S-cone syndrome and retinitis pigment ...[more]