Age of puberty and Sleep duration: Observational and Mendelian randomization study.

ABSTRACT: Earlier age of puberty has detrimental consequences for many aspects of health. Here, for the first time, we assessed the association of earlier puberty with sleep duration observationally and with validation using Mendelian Randomization. In the "Children of 1997" birth cohort (n = 8,327), we used adjusted multivariable logistic regression to assess the associations of each clinically assessed marker of earlier puberty with self-report sleep duration in adolescence. Using two-sample MR, we assessed the effect of earlier puberty timing based on 203 single nucleotide polymorphisms applied to genome wide association studies of sleep duration in adults (n = 335,410). In "Children of 1997", cross-sectionally, older age of menarche was associated with longer (9+ hours) sleep duration [odds rati

SUBMITTER: Wang J 

PROVIDER: S-EPMC7035269 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature