Optical coherence tomography shows neuroretinal thinning in myelopathy of adrenoleukodystrophy.

ABSTRACT:

Background

Progressive myelopathy is the main cause of disability in adrenoleukodystrophy (ALD). Development of therapies is hampered by a lack of quantitative outcome measures. In this study, we investigated whether myelopathy in ALD is associated with retinal neurodegeneration on optical coherence tomography (OCT), which could serve as a surrogate outcome measure.

Methods

Sixty-two patients (29 men and 33 women) and 70 age-matched and sex-matched controls (33 men and 37 women) were included in this cross-sectional study. We compared retinal nerve fiber layer (RNFL), ganglion cell layer (GCL) and peripapillary retinal nerve fiber layer (pRNFL) thickness between ALD patients and controls. In addition, we correlated these OCT measurements with clinical parameters of severity

SUBMITTER: van Ballegoij WJC 

PROVIDER: S-EPMC7035302 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature