Hepcidin-mediated Iron Regulation in P19 Cells is Detectable by Magnetic Resonance Imaging.

ABSTRACT: Magnetic resonance imaging can be used to track cellular activities in the body using iron-based contrast agents. However, multiple intrinsic cellular iron handling mechanisms may also influence the detection of magnetic resonance (MR) contrast: a need to differentiate among those mechanisms exists. In hepcidin-mediated inflammation, for example, downregulation of iron export in monocytes and macrophages involves post-translational degradation of ferroportin. We examined the influence of hepcidin endocrine activity on iron regulation and MR transverse relaxation rates in multi-potent P19 cells, which display high iron import and export activities, similar to alternatively-activated macrophages. Iron import and export were examined in cultured P19 cells in the presence and absence of iron-s

SUBMITTER: Alizadeh K 

PROVIDER: S-EPMC7035373 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature