The extracytoplasmic function sigma factor σ^VreI is active during infection and contributes to phosphate starvation-induced virulence of Pseudomonas aeruginosa.

ABSTRACT: The extracytoplasmic function sigma factor σ^VreI of the human pathogen Pseudomonas aeruginosa promotes transcription of potential virulence determinants, including secretion systems and secreted proteins. Its activity is modulated by the VreR anti-σ factor that inhibits the binding of σ^VreI to the RNA polymerase in the absence of a (still unknown) inducing signal. The vreI-vreR genes are expressed under inorganic phosphate (Pi) starvation, a physiological condition often encountered in the host that increases P. aeruginosa pathogenicity. However, whether or not σ^VreI is active in vivo during infection and contributes to the Pi starvation-induced virulence of this pathogen has not been analyzed yet. Using zebrafish embryos and a human alveolar basal epitheli

SUBMITTER: Otero-Asman JR 

PROVIDER: S-EPMC7035377 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature