ILoF: An intelligent Lab on Fiber Approach for Human Cancer Single-Cell Type Identification.

ABSTRACT: With the advent of personalized medicine, there is a movement to develop "smaller" and "smarter" microdevices that are able to distinguish similar cancer subtypes. Tumor cells display major differences when compared to their natural counterparts, due to alterations in fundamental cellular processes such as glycosylation. Glycans are involved in tumor cell biology and they have been considered to be suitable cancer biomarkers. Thus, more selective cancer screening assays can be developed through the detection of specific altered glycans on the surface of circulating cancer cells. Currently, this is only possible through time-consuming assays. In this work, we propose the "intelligent" Lab on Fiber (iLoF) device, that has a high-resolution, and which is a fast and portable method for tumor s

SUBMITTER: Paiva JS 

PROVIDER: S-EPMC7035380 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature