Oxidant stress and renal function among children with chronic kidney disease: a repeated measures study.

ABSTRACT: It is hypothesized that chronic kidney disease (CKD) induces oxidant stress which contributes to the decline in kidney function. However, few studies have incorporated longitudinal designs and no studies have investigated this association among children. Using data from the Chronic Kidney Disease in Children (CKiD) study, we examined longitudinal associations between urinary biomarkers of oxidant stress, 8-OH deoxyguanosine (8-OHdG) and F2-isoprostane, and measures of renal function and blood pressure among children with CKD. Baseline levels of 8-OHdG were positively associated with estimated glomerular filtration rate (eGFR) over time and a log-unit increase in baseline 8-OHdG predicted a 5.68 ml/min/1.73 m² increase in eGFR (95% Confidence Interval (CI): 3.75, 7.61). This asso

SUBMITTER: Jacobson MH 

PROVIDER: S-EPMC7035390 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature