Individual-specific functional connectivity of the amygdala: A substrate for precision psychiatry.

ABSTRACT: The amygdala is central to the pathophysiology of many psychiatric illnesses. An imprecise understanding of how the amygdala fits into the larger network organization of the human brain, however, limits our ability to create models of dysfunction in individual patients to guide personalized treatment. Therefore, we investigated the position of the amygdala and its functional subdivisions within the network organization of the brain in 10 highly sampled individuals (5 h of fMRI data per person). We characterized three functional subdivisions within the amygdala of each individual. We discovered that one subdivision is preferentially correlated with the default mode network; a second is preferentially correlated with the dorsal attention and fronto-parietal networks; and third subdivision do

SUBMITTER: Sylvester CM 

PROVIDER: S-EPMC7035483 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature