Distinct Growth Phases in Early Life Associated With the Risk of Type 1 Diabetes: The TEDDY Study.

ABSTRACT:

Objective

This study investigates two-phase growth patterns in early life and their association with development of islet autoimmunity (IA) and type 1 diabetes (T1D).

Research design and methods

The Environmental Determinants of Diabetes in the Young (TEDDY) study followed 7,522 genetically high-risk children in Sweden, Finland, Germany, and the U.S. from birth for a median of 9.0 years (interquartile range 5.7-10.6) with available growth data. Of these, 761 (10.1%) children developed IA and 290 (3.9%) children were diagnosed with T1D. Bayesian two-phase piecewise linear mixed models with a random change point were used to estimate children's individual growth trajectories. Cox proportional hazards models were used to assess the effects of associated growth parameters on the

SUBMITTER: Liu X 

PROVIDER: S-EPMC7035588 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature