Excess BMI Accelerates Islet Autoimmunity in Older Children and Adolescents.

ABSTRACT:

Objective

Sustained excess BMI increases the risk of type 1 diabetes (T1D) in autoantibody-positive relatives without diabetes of patients. We tested whether elevated BMI also accelerates the progression of islet autoimmunity before T1D diagnosis.

Research design and methods

We studied 706 single autoantibody-positive pediatric TrialNet participants (ages 1.6-18.6 years at baseline). Cumulative excess BMI (ceBMI) was calculated for each participant based on longitudinally accumulated BMI ≥85th age- and sex-adjusted percentile. Recursive partitioning analysis and multivariable modeling defined the age cut point differentiating the risk for progression to multiple positive autoantibodies.

Results

At baseline, 175 children (25%) had a BMI ≥85th percentile. ceBMI range wa

SUBMITTER: Ferrara-Cook C 

PROVIDER: S-EPMC7035590 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature