Sex difference in dopamine D1-D2 receptor complex expression and signaling affects depression- and anxiety-like behaviors.

ABSTRACT: Depression and anxiety are more common among females than males and represent a leading cause of disease-related disability in women. Since the dopamine D1-D2 heteromer is involved in depression- and anxiety-like behavior, the possibility that the receptor complex may have a role in mediating sex differences in such behaviors and related biochemical signaling was explored.In non-human primate caudate nucleus and in rat striatum, females expressed higher density of D1-D2 heteromer complexes and a greater number of D1-D2 expressing neurons compared to males. In rat, the sex difference in D1-D2 expression levels occurred even though D1 receptor expression was lower in female than in male with no difference in D2 receptor expression. In behavioral tests, female rats showed faster latency to de

SUBMITTER: Hasbi A 

PROVIDER: S-EPMC7035642 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature