BOLD differences normally attributed to inhibitory control predict symptoms, not task-directed inhibitory control in ADHD.

ABSTRACT:

Background

Altered brain activity that has been observed in attention deficit hyperactivity disorder (ADHD) while performing cognitive control tasks like the stop signal task (SST) has generally been interpreted as reflecting either weak (under-active) or compensatory (over-active) versions of the same functions as in healthy controls. If so, then regional activities that correlate with the efficiency of inhibitory control (i.e. stop signal reaction time, SSRT) in healthy subjects should also correlate with SSRT in ADHD. Here we test the alternate hypothesis that BOLD (blood-oxygen-level-dependent) differences might instead reflect the redirection of neural processing resources normally used for task-directed inhibitory control, towards actively managing symptomatic behaviour. If s

SUBMITTER: Chevrier A 

PROVIDER: S-EPMC7035717 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature