Preterm birth impairs postnatal lung development in the neonatal rabbit model.

ABSTRACT:

Background

Bronchopulmonary dysplasia continues to cause important respiratory morbidity throughout life, and new therapies are needed. The common denominator of all BPD cases is preterm birth, however most preclinical research in this area focusses on the effect of hyperoxia or mechanical ventilation. In this study we investigated if and how prematurity affects lung structure and function in neonatal rabbits.

Methods

Pups were delivered on either day 28 or day 31. For each gestational age a group of pups was harvested immediately after birth for lung morphometry and surfactant protein B and C quantification. All other pups were hand raised and harvested on day 4 for the term pups and day 7 for the preterm pups (same corrected age) for lung morphometry, lung function testing

SUBMITTER: Salaets T 

PROVIDER: S-EPMC7035772 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature