Colonic mucosal and serum expression of microRNAs in canine large intestinal inflammatory bowel disease.

ABSTRACT: BACKGROUND:Canine inflammatory bowel disease (IBD) is a group of chronic gastrointestinal (GI) disorders of still largely unknown etiology. Canine IBD diagnosis is time-consuming and costly as other diseases with similar signs should be initially excluded. In human IBD microRNA (miR) expression changes have been reported in GI mucosa and blood. Thus, there is a possibility that miRs may provide insight into disease pathogenesis, diagnosis and even treatment of canine IBD. The aim of this study was to determine the colonic mucosal and serum relative expression of a miRs panel in dogs with large intestinal IBD and healthy control dogs. RESULTS:Compared to healthy control dogs, dogs with large intestinal IBD showed significantly increased relative expression of miR-16, miR-21, miR-122 and miR

SUBMITTER: Konstantinidis AΟ 

PROVIDER: S-EPMC7035774 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature