The E2F family as potential biomarkers and therapeutic targets in colon cancer.

ABSTRACT:

Background

The E2F family is a group of genes encoding a series of transcription factors in higher eukaryotes and participating in the regulation of cell cycle and DNA synthesis in mammals. This study was designed to investigate the role of E2F family in colon cancer.

Methods

In this study, the transcriptional levels of E2F1-8 in patients with colon cancer from GEPIA was examined. Meanwhile, the immunohistochemical data of the eight genes were also obtained in the The Human Protein Atlas website. Additionally, we re-identified the mRNA expression levels of these genes via real time PCR. Furthermore, the association between the levels of E2F family and stage plot as wells overall survival of patients with colon cancer were analyzed.

Results

We found that the mRNA and p

SUBMITTER: Yao H 

PROVIDER: S-EPMC7035869 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature