Keratinocyte interleukin-36 receptor expression orchestrates psoriasiform inflammation in mice.

ABSTRACT: The IL-36 family cytokines have emerged as important mediators of dermal inflammation in psoriasis and have been reported to provide a proinflammatory stimulus to a variety of immune and stromal cell subsets in the inflamed skin. However, it remains to be determined which cell type, if any, in the skin plays a predominant role in mediating IL-36 cytokines instructive role in disease. Here, we demonstrate that targeted deletion of Il36r in keratinocytes results in similar levels of protection from psoriasiform inflammation observed in "global" Il36r-deficient mice. Mice with deficiency in IL-36 receptor expression on keratinocytes had significantly decreased expression, comparable with Il36r-deficient mice, of established mediators of psoriatic inflammation, including, IL-17a, IL-23, IL-22,

SUBMITTER: Hernandez-Santana YE 

PROVIDER: S-EPMC7035875 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature