Myofiber Architecture of the Human Atria as Revealed by Submillimeter Diffusion Tensor Imaging.

ABSTRACT:

Background

Accurate knowledge of the human atrial fibrous structure is paramount in understanding the mechanisms of atrial electric function in health and disease. Thus far, such knowledge has been acquired from destructive sectioning, and there is a paucity of data about atrial fiber architecture variability in the human population.

Methods and results

In this study, we have developed a customized 3-dimensional diffusion tensor magnetic resonance imaging sequence on a clinical scanner that makes it possible to image an entire intact human heart specimen ex vivo at submillimeter resolution. The data from 8 human atrial specimens obtained with this technique present complete maps of the fibrous organization of the human atria. The findings demonstrate that the main features o

SUBMITTER: Pashakhanloo F 

PROVIDER: S-EPMC7035884 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature