Regulation of OmpA Translation and Shigella dysenteriae Virulence by an RNA Thermometer.

ABSTRACT: RNA thermometers are cis-acting riboregulators that mediate the posttranscriptional regulation of gene expression in response to environmental temperature. Such regulation is conferred by temperature-responsive structural changes within the RNA thermometer that directly result in differential ribosomal binding to the regulated transcript. The significance of RNA thermometers in controlling bacterial physiology and pathogenesis is becoming increasingly clear. This study combines in silico, molecular genetics, and biochemical analyses to characterize both the structure and function of a newly identified RNA thermometer within the ompA transcript of Shigella dysenteriae First identified by in silico structural predictions, genetic analyses have demonstrated that the ompA RNA thermometer is a

SUBMITTER: Murphy ER 

PROVIDER: S-EPMC7035939 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature