The effects of genetic variants related to insulin metabolism pathways and the interactions with lifestyles on colorectal cancer risk.

ABSTRACT:

Objectives

Genetic variants in metabolic signaling pathways may interact with lifestyle factors, such as dietary fatty acids, influencing postmenopausal colorectal cancer (CRC) risk, but these interrelated pathways are not fully understood.

Methods

In this study, we examined 54 single-nucleotide polymorphisms (SNPs) in genes related to insulin-like growth factor-I/insulin traits and their signaling pathways and lifestyle factors in relation to postmenopausal CRC, using data from 6,539 postmenopausal women in the Women's Health Initiative Harmonized and Imputed Genome-Wide Association Studies. By employing a two-stage random survival forest analysis, we evaluated the SNPs and lifestyle factors by ranking them according to their predictive value and accuracy for CRC.

Result

SUBMITTER: Jung SY 

PROVIDER: S-EPMC7035960 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature