The impact of fluid balance on outcomes in premature neonates: a report from the AWAKEN study group.

ABSTRACT:

Background

We evaluated the epidemiology of fluid balance (FB) over the first postnatal week and its impact on outcomes in a multi-center cohort of premature neonates from the AWAKEN study.

Methods

Retrospective analysis of infants <36 weeks' gestational age from the AWAKEN study (N = 1007). FB was defined by percentage of change from birth weight.

Outcome

Mechanical ventilation (MV) at postnatal day 7.

Results

One hundred and forty-nine (14.8%) were on MV at postnatal day 7. The median peak FB was 0% (IQR: -2.9, 2) and occurred on postnatal day 2 (IQR: 1,5). Multivariable models showed that the peak FB (aOR 1.14, 95% CI 1.10-1.19), lowest FB in first postnatal week (aOR 1.12, 95% CI 1.07-1.16), and FB on postnatal day 7 (aOR 1.10, 95% CI 1.06-1.13) were indepe

SUBMITTER: Selewski DT 

PROVIDER: S-EPMC7036003 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature