A functional SNP in the synaptic SNAP25 gene is associated with impulsivity in a Colombian sample.

ABSTRACT: The aim of the current study was to test the hypothesis that a functional polymorphism in the synaptosome associated protein 25 (SNAP25) gene could be associated with impulsivity scores in a sample of young Colombian subjects. Impulsivity has been postulated as an endophenotype for several psychiatric disorders of high epidemiological relevance. There is a need for the study of additional candidate genes for impulsivity. One hundred seventy-five young Colombian subjects completed the Spanish version of the short form of the Barratt Impulsiveness Scale (BIS-15S). A TaqMan assay was used to genotype a functional polymorphism (rs3746544) in the SNAP25 gene. A significant association was found between the functional polymorphism in the SNAP25 gene and impulsivity in the Co

SUBMITTER: Gonzalez-Giraldo Y 

PROVIDER: S-EPMC7036081 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature