Identification and clinical impact of potentially actionable somatic oncogenic mutations in solid tumor samples.

ABSTRACT:

Background

An increasing number of anti-cancer therapeutic agents target specific mutant proteins that are expressed by many different tumor types. Successful use of these therapies is dependent on the presence or absence of somatic mutations within the patient's tumor that can confer clinical efficacy or drug resistance.

Methods

The aim of our study was to determine the type, frequency, overlap and functional proteomic effects of potentially targetable recurrent somatic hotspot mutations in 47 cancer-related genes in multiple disease sites that could be potential therapeutic targets using currently available agents or agents in clinical development.

Results

Using MassArray technology, of the 1300 patient tumors analysed 571 (43.9%) had at least one somatic mutation.

SUBMITTER: Toomey S 

PROVIDER: S-EPMC7036178 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature